February 10 - Sleeping sickness. Could parasite-secreted proteins contribute to tissue invasion

 


African Trypanosomiasis, also known as sleeping sickness, is a neglected tropical disease that affects human and a wide range of mammalian hosts. Although it is mostly geographically restricted to Africa, cases have been detected in every continent due to increasing tourism to endemic countries. This parasitic disease is caused by Trypanosoma brucei species parasites and is transmitted by the bite of infected tsetse flies. In this talk, we will review the epidemiology, clinical presentation, current diagnostics and treatments of the disease. We will also discuss my current PhD project, which involves identifying the role of parasite-secreted proteins in the establishment of sleeping sickness and tissue invasion, as well as their mechanism of release.

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